SYNDIG1L

Across TCGA pan-cancer cohorts, SYNDIG1L RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SYNDIG1L data layer compared with 7 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SYNDIG1L RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SYNDIG1L expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, CESC, and THCA are the cancer types where SYNDIG1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.703	0.539	<.001	81	view →
CESC	OS	Tertile	IV	0.699	0.260	.007	54	view →
THCA	DFS	Tertile	II,III,IV	0.954	0.266	.001	51	view →
BLCA	OS	Tertile	IV	0.132	0.447	.003	49	view →
HNSC	DFS	Tertile	IV	0.438	0.220	.001	38	view →
COAD	DFS	Tertile	All	0.673	0.859	<.001	35	view →
BRCA	OS	Quartile	III,IV	0.910	0.758	.010	19	view →
PCPG	DFS	Tertile	All	0.961	0.807	.009	18	view →
GBM	OS	Tertile	All	0.342	0.518	.001	18	view →
SARC	OS	Median	All	0.825	0.635	.005	16	view →
SCLC	OS	Tertile	All	0.624	0.305	.003	15	view →
LUSC	OS	Median	All	0.741	0.882	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SYNDIG1L–SKCM (DFS)

Open the SKCM breakdown →