SYNDIG1L

Across TCGA pan-cancer cohorts, SYNDIG1L RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SYNDIG1L’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SYNDIG1L RNA is repressed in tumor relative to normal tissue. In most cancer types SYNDIG1L is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, THCA, and LUSC are the cancer types where SYNDIG1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYNDIG1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−2.310	<.001	11	view →
THCA	Male	III,IV	+2.121	<.001	10	view →
LUSC	Female	II,III,IV	−2.427	<.001	9	view →
READ	All	All	−0.372	<.001	7	view →
COAD	All	All	−0.287	<.001	7	view →
BRCA	All	III,IV	−0.265	<.001	6	view →
KICH	Female	All	+1.031	.001	4	view →
STAD	Male	All	−0.241	.006	3	view →
BLCA	All	IV	−0.201	.030	2	view →
CHOL	All	All	+0.160	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SYNDIG1L–LUAD

Open the LUAD breakdown →