SYNDIG1L

Across TCGA cell cohorts, SYNDIG1L mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNDIG1L-associated genes across cancer lineages are KLHL40, OR2M5, and CCDC172. Each is linked with SYNDIG1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNDIG1L-to-partner and partner-to-SYNDIG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by SYNDIG1L-low versus SYNDIG1L-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNDIG1L→partner) and Y-score (partner→SYNDIG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KLHL40 →	+0.006	+4.273	<.001	.006	3	1
LARGE_INTESTINE	OR2M5 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	CCDC172 →	+0.006	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

KLHL40 by SYNDIG1L expression — SKIN

Explore this box plot interactively →