SYNDIG1

Across TCGA patient cohorts, SYNDIG1 mutation is significantly associated with the RNA expression of many other genes, with 2,413 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNDIG1-associated genes across cancer lineages are LINC01941, SNORD38C, and TRGJP2. Each is linked with SYNDIG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYNDIG1-to-partner and partner-to-SYNDIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01941 grouped by SYNDIG1-low versus SYNDIG1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNDIG1→partner) and Y-score (partner→SYNDIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC01941 →	+0.188	+4.669	<.001	.007	3	3
CESC	SNORD38C →	+0.557	+4.320	.002	.007	3	2
BLCA	TRGJP2 →	+0.661	+3.266	.001	.009	3	2
LUSC	MIR31 →	+0.597	+3.277	<.001	.005	3	2
LUSC	PAFAH1B1P1 →	+0.084	+4.358	.001	<.001	3	2
LUSC	RN7SKP202 →	+0.381	+4.780	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,413 associations by consensus.

LINC01941 by SYNDIG1 expression — CESC

Explore this box plot interactively →