SYNDIG1

Across TCGA pan-cancer cohorts, SYNDIG1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SYNDIG1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SYNDIG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SYNDIG1 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

HNSC, THCA, and KIRP are the cancer types where SYNDIG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYNDIG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+1.101	<.001	12	view →
THCA	Male	III,IV	−3.115	<.001	11	view →
KIRP	Female	II,III,IV	−2.786	<.001	11	view →
LUAD	Male	II,III,IV	+1.469	<.001	9	view →
COAD	All	All	+0.629	<.001	9	view →
KICH	Female	All	−2.918	<.001	8	view →
BRCA	All	III,IV	+2.280	<.001	8	view →
STAD	Male	II,III,IV	+1.528	<.001	6	view →
BLCA	Female	III,IV	+1.267	.003	6	view →
LUSC	Male	II,III,IV	+1.732	<.001	5	view →
LIHC	All	All	+0.237	.005	4	view →
PAAD	All	All	+1.252	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SYNDIG1–HNSC

Open the HNSC breakdown →