SYCN

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SYCN RNA expression is significantly associated with the protein abundance of many other proteins, with 8,133 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SYCN-associated proteins across cancer lineages are RPS18, RGP1, and ROMO1. Each is linked with SYCN in more than 2 cancer types. Because this analysis shows association rather than direction, both SYCN-to-partner and partner-to-SYCN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYCN versus RPS18 in HNSC, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCN→partner) and Y-score (partner→SYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCRPS18 →+0.243+0.669.003.00533
PDACRGP1 →-0.307-2.909.002.00132
PDACROMO1 →+0.616+3.943.001<.00132
UCECSCML2_S511 →+0.366+0.214.002.00932
LSCCSH3BGRL →-0.292-0.256.003.00832
HNSCSLC2A10_S527 →-0.619-0.684<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 8,133 associations by consensus.

SYCN vs RPS18 — HNSC

Per-sample scatter of SYCN vs RPS18 in HNSC (Pearson r = 0.31).

Explore this scatter interactively →

Exploration