SYCN

Across TCGA pan-cancer cohorts, SYCN RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated SYCN data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher SYCN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SYCN expression acts as an unfavorable survival marker, although some lineages such as UCS and ESCA show a favorable association.

SCLC, READ, and COAD are the cancer types where SYCN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	II,III,IV	0.164	0.819	<.001	54	view →
READ	OS	Tertile	II,III,IV	0.083	0.919	<.001	54	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	45	view →
UCS	DFS	Tertile	II,III,IV	0.681	0.261	.010	36	view →
THYM	OS	Tertile	All	0.454	0.962	.002	24	view →
LUAD	DFS	Tertile	III,IV	0.299	0.526	.025	24	view →
PAAD	OS	Quartile	All	0.345	0.718	.003	18	view →
THCA	OS	Tertile	III,IV	0.585	0.887	.006	18	view →
ESCA	DFS	Median	III,IV	0.537	0.324	.014	18	view →
KIRP	OS	Tertile	All	0.825	0.944	.003	15	view →
BLCA	DFS	Tertile	II,III,IV	0.525	0.656	.013	13	view →
ACC	DFS	Tertile	All	0.781	0.509	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

SYCN–SCLC (OS)

Open the SCLC breakdown →