SYCN

Across TCGA pan-cancer cohorts, SYCN RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SYCN’s most consistent transcriptional readouts.

The strongest signal is observed in esophageal carcinoma (ESCA), where SYCN RNA is repressed in tumor relative to normal tissue. In most cancer types SYCN is over-expressed in tumor, although a few such as ESCA and HNSC show the opposite, repressed pattern.

ESCA, HNSC, and LUAD are the cancer types where SYCN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYCN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
ESCA	All	All	−1.063	<.001	4	view →
HNSC	All	All	−0.133	.003	4	view →
LUAD	All	All	−0.057	.005	3	view →
STAD	Male	II,III,IV	−0.319	.031	1	view →
LIHC	All	All	+0.053	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SYCN–ESCA

Open the ESCA breakdown →