SYCN

Across TCGA patient cohorts, SYCN protein abundance is significantly associated with the RNA expression of many other genes, with 819 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SYCN-associated genes across cancer lineages are PPIL2, ESS2, and SLC25A1. Each is linked with SYCN in more than 1 cancer types. Because this analysis shows association rather than direction, both SYCN-to-partner and partner-to-SYCN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYCN versus PPIL2 in PDAC, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCN→partner) and Y-score (partner→SYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPIL2 →	-0.223	-0.785	.002	.004	3	1
PDAC	ESS2 →	-0.150	-0.511	.001	.006	3	1
PDAC	SLC25A1 →	-0.390	-0.901	<.001	.001	3	1
PDAC	TRIOBP →	-0.398	-0.925	<.001	<.001	3	1
PDAC	DDX17 →	-0.222	-0.692	.004	.001	3	1
PDAC	CBY1 →	-0.255	-0.804	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 819 associations by consensus.

SYCN vs PPIL2 — PDAC

Explore this scatter interactively →