SYCN

Across TCGA patient cohorts, SYCN mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYCN-associated genes across cancer lineages are RBAK-RBAKDN, MIR7848, and GAPDHP24. Each is linked with SYCN in more than 1 cancer types. Because this analysis shows association rather than direction, both SYCN-to-partner and partner-to-SYCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBAK-RBAKDN grouped by SYCN-low versus SYCN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCN→partner) and Y-score (partner→SYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RBAK-RBAKDN →	+0.108	+3.727	.008	.006	3	1
UCEC	MIR7848 →	+0.688	+3.153	.009	.006	3	1
UCEC	GAPDHP24 →	+0.185	+3.001	<.001	.009	3	1
UCEC	TRAJ20 →	+0.937	+3.329	<.001	.004	3	1
UCEC	RN7SKP279 →	+0.127	+4.400	.003	.006	3	1
UCEC	RPS29P9 →	+0.321	+3.086	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

RBAK-RBAKDN by SYCN expression — UCEC

Explore this box plot interactively →