SYCN

Across TCGA cell cohorts, SYCN RNA expression is significantly associated with the mutation status of many other genes, with 150 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYCN-associated genes across cancer lineages are TMCC2, DLG1, and WDR47. Each is linked with SYCN in more than 1 cancer types. Because this analysis shows association rather than direction, both SYCN-to-partner and partner-to-SYCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCC2 grouped by SYCN-low versus SYCN-high in BLOOD_Leukemia.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCN→partner) and Y-score (partner→SYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMCC2 →	+4.539	+0.037	.007	<.001	3	2
BLOOD_Leukemia	DLG1 →	+4.539	+0.035	.007	<.001	3	2
BLOOD_Lymphoma	WDR47 →	+4.247	+0.025	.004	<.001	3	1
BLOOD_Leukemia	AGAP1 →	+4.124	+0.040	<.001	<.001	3	1
BLOOD_Leukemia	DIP2A →	+3.316	+0.028	.003	<.001	3	1
BLOOD_Leukemia	PRMT2 →	+4.539	+0.035	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

TMCC2 by SYCN expression — BLOOD_Leukemia

Explore this box plot interactively →