SYAP1

Across TCGA patient cohorts, SYAP1 mutation is significantly associated with the RNA expression of many other genes, with 666 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYAP1-associated genes across cancer lineages are OR51G1, RNU6-679P, and HMGN1P19. Each is linked with SYAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYAP1-to-partner and partner-to-SYAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51G1 grouped by SYAP1-low versus SYAP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYAP1→partner) and Y-score (partner→SYAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR51G1 →	+0.034	+7.731	<.001	.009	3	2
LGG	RNU6-679P →	+0.363	+7.977	<.001	.007	3	2
UCEC	HMGN1P19 →	+0.094	+2.677	.002	.005	3	2
UCEC	IGKV2-18 →	+0.323	+2.332	<.001	<.001	3	2
UCEC	DUSP15 →	-0.775	-3.660	.005	.001	3	1
UCEC	LTO1 →	+0.287	+3.483	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 666 associations by consensus.

OR51G1 by SYAP1 expression — BRCA

Explore this box plot interactively →