SYAP1

Across TCGA pan-cancer cohorts, SYAP1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SYAP1 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SYAP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SYAP1 expression acts as an unfavorable survival marker, although some lineages such as OV and KIRC show a favorable association.

KIRP, LUAD, and OV are the cancer types where SYAP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.784	0.957	<.001	116	view →
LUAD	DFS	Median	All	0.555	0.757	<.001	87	view →
OV	DFS	Tertile	III,IV	0.431	0.320	.001	68	view →
UVM	DFS	Tertile	III,IV	0.194	0.854	<.001	61	view →
HNSC	OS	Median	II,III,IV	0.698	0.810	.002	58	view →
LGG	OS	Median	All	0.749	0.867	<.001	42	view →
ACC	DFS	Tertile	All	0.287	0.729	<.001	41	view →
KIRC	DFS	Quartile	III,IV	0.783	0.422	.005	39	view →
CESC	DFS	Tertile	All	0.650	0.823	.004	28	view →
KICH	OS	Quartile	All	0.636	1.000	.004	25	view →
MESO	OS	Tertile	All	0.423	0.633	.011	22	view →
PRAD	DFS	Tertile	All	0.952	0.908	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SYAP1–KIRP (OS)

Open the KIRP breakdown →