SYAP1

Across TCGA pan-cancer cohorts, SYAP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SYAP1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SYAP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SYAP1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LUAD, HNSC, and THCA are the cancer types where SYAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+0.809	<.001	11	view →
HNSC	Male	All	+0.365	.002	8	view →
THCA	All	All	−0.321	<.001	7	view →
BRCA	All	III,IV	+0.898	<.001	6	view →
UCEC	All	All	+0.465	.010	6	view →
STAD	All	II,III,IV	+0.488	.001	5	view →
BLCA	Male	IV	+0.512	.005	4	view →
KICH	Female	All	−0.450	.007	3	view →
CHOL	All	All	+0.665	.011	2	view →
PRAD	All	All	+0.323	<.001	2	view →
LUSC	All	All	+0.268	.006	2	view →
COAD	Male	All	+0.292	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SYAP1–LUAD

Open the LUAD breakdown →