SWI5

Across TCGA patient cohorts, SWI5 mutation is significantly associated with the RNA expression of many other genes, with 138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SWI5-associated genes across cancer lineages are H2AB2, RNU6-694P, and SEPTIN14P5. Each is linked with SWI5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SWI5-to-partner and partner-to-SWI5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AB2 grouped by SWI5-low versus SWI5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SWI5→partner) and Y-score (partner→SWI5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	H2AB2 →	+0.134	+9.057	<.001	.003	3	2
BLCA	RNU6-694P →	+0.356	+4.704	<.001	.005	3	2
BRCA	SEPTIN14P5 →	+0.129	+8.055	<.001	.007	3	2
UCEC	GPC5-IT1 →	+0.226	+4.437	.005	.001	3	2
COAD	CEP19P1 →	+0.090	+4.666	<.001	.005	3	2
BRCA	LINC02336 →	+0.144	+8.471	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

H2AB2 by SWI5 expression — BRCA

Explore this box plot interactively →