SVIL2P

Across TCGA patient cohorts, SVIL2P mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SVIL2P-associated genes across cancer lineages are Caspase-8, MYH11, and NF-kB-p65_pS536. Each is linked with SVIL2P in more than 1 cancer types. Because this analysis shows association rather than direction, both SVIL2P-to-partner and partner-to-SVIL2P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by SVIL2P-low versus SVIL2P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVIL2P→partner) and Y-score (partner→SVIL2P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.295	-2.973	.025	.035	3	2
SKCM	MYH11 →	-0.904	-3.321	.043	.010	3	1
SKCM	NF-kB-p65_pS536 →	-0.503	-3.321	.013	.010	3	1
SKCM	AMPK_pT172 →	+0.426	+3.321	.012	.010	3	1
SKCM	TAZ →	+0.226	+2.824	.006	.034	3	1
SKCM	Bad_pS112 →	-0.272	-2.987	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-8 by SVIL2P expression — UCEC

Explore this box plot interactively →