SVIL2P

Across TCGA pan-cancer cohorts, SVIL2P RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SVIL2P’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SVIL2P RNA is repressed in tumor relative to normal tissue. In most cancer types SVIL2P is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

BLCA, UCEC, and BRCA are the cancer types where SVIL2P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SVIL2P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−1.216	.004	8	view →
UCEC	All	All	−1.137	<.001	6	view →
BRCA	Female	II,III,IV	−0.266	<.001	6	view →
COAD	All	II,III,IV	−0.522	<.001	4	view →
STAD	Female	All	−1.410	.010	3	view →
KIRC	All	All	+0.189	.003	3	view →
CHOL	All	All	+0.635	.005	2	view →
PRAD	All	All	−0.454	<.001	2	view →
KIRP	All	All	+0.200	.036	2	view →
LIHC	All	All	+0.095	.008	2	view →
READ	All	All	−1.023	.022	1	view →
KICH	All	All	−0.260	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SVIL2P–BLCA

Open the BLCA breakdown →