SULT1B1

Across TCGA cell cohorts, SULT1B1 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SULT1B1-associated genes across cancer lineages are OR2C1, GRM1, and TIFAB. Each is linked with SULT1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SULT1B1-to-partner and partner-to-SULT1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2C1 grouped by SULT1B1-low versus SULT1B1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SULT1B1→partner) and Y-score (partner→SULT1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2C1 →	+0.123	+3.047	<.001	.005	3	2
LARGE_INTESTINE	GRM1 →	+0.036	+3.546	<.001	.004	3	1
LARGE_INTESTINE	TIFAB →	+0.003	+3.240	<.001	.004	3	1
LARGE_INTESTINE	TBC1D3 →	+0.058	+2.688	<.001	.008	3	1
LARGE_INTESTINE	WSCD2 →	+0.109	+2.923	.001	.004	3	1
OVARY	OR12D3 →	+0.010	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

OR2C1 by SULT1B1 expression — LARGE_INTESTINE

Explore this box plot interactively →