STX19

Across TCGA patient cohorts, STX19 mutation is significantly associated with the RNA expression of many other genes, with 914 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX19-associated genes across cancer lineages are SNX3P1Y, MIR4692, and YTHDF3-AS1. Each is linked with STX19 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX19-to-partner and partner-to-STX19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX3P1Y grouped by STX19-low versus STX19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX19→partner) and Y-score (partner→STX19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNX3P1Y →	+0.127	+4.893	<.001	.001	3	2
SKCM	MIR4692 →	+0.547	+6.080	<.001	.002	3	2
UCEC	YTHDF3-AS1 →	+0.706	+2.638	.001	.005	3	1
UCEC	CCL5 →	+1.337	+3.721	.001	<.001	3	1
UCEC	MIR6859-2 →	+0.347	+2.690	.001	.001	3	1
UCEC	RN7SL663P →	-0.456	-3.700	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 914 associations by consensus.

SNX3P1Y by STX19 expression — UCEC

Explore this box plot interactively →