STX19

Across TCGA pan-cancer cohorts, STX19 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of STX19’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where STX19 RNA is repressed in tumor relative to normal tissue. In most cancer types STX19 is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and BRCA are the cancer types where STX19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STX19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−1.338	<.001	12	view →
KIRC	Male	II,III,IV	−0.823	<.001	11	view →
BRCA	All	III,IV	−1.434	<.001	8	view →
LUAD	Female	III,IV	−1.336	<.001	7	view →
KICH	Male	All	−1.005	<.001	7	view →
UCEC	All	All	+1.942	<.001	6	view →
KIRP	All	All	−0.468	<.001	6	view →
COAD	Female	All	−1.661	<.001	5	view →
LUSC	All	All	−0.645	<.001	5	view →
PRAD	All	All	+1.688	<.001	2	view →
CHOL	All	All	+1.390	.001	2	view →
THCA	All	All	+0.137	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

STX19–HNSC

Open the HNSC breakdown →