STX18-AS1

Across TCGA pan-cancer cohorts, STX18-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated STX18-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher STX18-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated STX18-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

UCS, READ, and THCA are the cancer types where STX18-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	II,III,IV	0.622	0.217	.001	112	view →
READ	OS	Median	II,III,IV	0.797	0.300	<.001	82	view →
THCA	OS	Tertile	All	0.942	1.000	.005	53	view →
KIRP	DFS	Median	IV	0.039	0.623	.001	36	view →
PAAD	DFS	Quartile	All	0.655	0.355	.003	30	view →
ACC	DFS	Quartile	All	0.560	0.848	.004	28	view →
BRCA	DFS	Tertile	III,IV	0.945	0.802	.006	26	view →
LGG	DFS	Quartile	All	0.911	0.697	<.001	20	view →
STAD	DFS	Quartile	All	0.790	0.583	.006	19	view →
UCEC	OS	Tertile	III,IV	0.919	0.777	.007	18	view →
LIHC	DFS	Tertile	II,III,IV	0.304	0.513	.010	18	view →
CHOL	OS	Tertile	All	0.829	0.468	.012	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

STX18-AS1–UCS (OS)

Open the UCS breakdown →