STX18-AS1

Across TCGA pan-cancer cohorts, STX18-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of STX18-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where STX18-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types STX18-AS1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and COAD are the cancer types where STX18-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STX18-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.469	<.001	12	view →
THCA	Male	III,IV	−0.658	<.001	11	view →
COAD	Male	II,III,IV	+0.381	<.001	9	view →
LIHC	Female	All	+0.285	<.001	7	view →
STAD	All	II,III,IV	+0.457	<.001	6	view →
CHOL	Male	All	+0.676	<.001	5	view →
READ	All	All	+0.425	.004	3	view →
BLCA	All	All	+0.229	.049	2	view →
LUSC	All	All	+0.148	.014	2	view →
LUAD	All	All	+0.144	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

STX18-AS1–KIRC

Open the KIRC breakdown →