STRADB

Across TCGA patient cohorts, STRADB mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRADB-associated genes across cancer lineages are A-Raf_pS299, JNK2, and Ku80. Each is linked with STRADB in more than 1 cancer types. Because this analysis shows association rather than direction, both STRADB-to-partner and partner-to-STRADB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by STRADB-low versus STRADB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRADB→partner) and Y-score (partner→STRADB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.221	-3.584	<.001	.002	3	1
UCEC	JNK2 →	+0.231	+3.331	.012	.005	3	1
UCEC	Ku80 →	+0.361	+2.598	.001	.006	3	1
UCEC	Notch1 →	+0.214	+2.584	.001	.011	3	1
UCEC	PCNA →	+0.224	+2.584	.026	.011	3	1
UCEC	PDCD4 →	-0.459	-2.584	.036	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

A-Raf_pS299 by STRADB expression — UCEC

Explore this box plot interactively →