STRADB

Across TCGA pan-cancer cohorts, STRADB RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated STRADB data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher STRADB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STRADB expression acts as an unfavorable survival marker, although some lineages such as THCA and READ show a favorable association.

UVM, THCA, and KIRP are the cancer types where STRADB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.388	0.809	<.001	144	view →
THCA	OS	Median	All	0.981	0.896	.001	84	view →
KIRP	DFS	Median	All	0.861	0.956	<.001	64	view →
ACC	DFS	Tertile	All	0.447	0.761	.005	34	view →
LIHC	OS	Median	III,IV	0.371	0.710	<.001	34	view →
DLBC	DFS	Tertile	All	0.605	0.934	.017	29	view →
UCEC	OS	Tertile	All	0.821	0.902	.013	24	view →
KICH	OS	Quartile	II,III,IV	0.407	0.917	.008	16	view →
READ	OS	Median	II,III,IV	0.818	0.425	.015	14	view →
UCS	DFS	Quartile	III,IV	0.464	0.150	.038	12	view →
ESCA	OS	Tertile	IV	0.922	0.247	.024	12	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.461	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

STRADB–UVM (DFS)

Open the UVM breakdown →