STRADB

Across TCGA pan-cancer cohorts, STRADB RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of STRADB’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where STRADB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STRADB is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

THCA, KICH, and COAD are the cancer types where STRADB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STRADB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	+0.872	<.001	10	view →
KICH	Female	All	−1.404	<.001	8	view →
COAD	Female	All	−1.236	<.001	8	view →
BLCA	Female	All	+0.473	.004	6	view →
BRCA	All	All	−0.407	<.001	6	view →
UCEC	All	All	+0.370	.037	6	view →
HNSC	Male	All	−0.648	<.001	5	view →
LUAD	Male	II,III,IV	+0.646	.005	5	view →
READ	All	II,III,IV	−0.947	.011	4	view →
PRAD	All	All	+0.717	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

STRADB–THCA

Open the THCA breakdown →