STRA8

Across TCGA patient cohorts, STRA8 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRA8-associated genes across cancer lineages are c-Met_pY1235, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with STRA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both STRA8-to-partner and partner-to-STRA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by STRA8-low versus STRA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRA8→partner) and Y-score (partner→STRA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.109	+3.009	.011	.019	3	2
UCEC	EGFR_pY1068 →	-0.351	-3.000	.015	.037	3	1
UCEC	JNK_pT183_Y185 →	-0.251	-2.999	.009	.035	3	1
UCEC	JNK2 →	+0.289	+2.817	.012	.036	3	1
UCEC	PCNA →	+0.312	+3.000	.012	.037	2	2
UCEC	Bax →	+0.442	+2.817	.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

c-Met_pY1235 by STRA8 expression — UCEC

Explore this box plot interactively →