STRA8

Across TCGA pan-cancer cohorts, STRA8 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of STRA8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where STRA8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STRA8 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where STRA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STRA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+1.742	<.001	12	view →
KICH	Male	All	−0.845	<.001	11	view →
HNSC	All	All	+0.626	<.001	10	view →
KIRP	Male	All	+0.838	<.001	6	view →
LIHC	All	All	+0.310	<.001	6	view →
LUSC	All	All	+0.640	<.001	4	view →
BRCA	Female	All	+0.274	<.001	4	view →
STAD	All	All	+0.454	.012	2	view →
LUAD	All	All	+0.202	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

STRA8–KIRC

Open the KIRC breakdown →