STRA8

Across TCGA pan-cancer cohorts, STRA8 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated STRA8 data layer compared with 7 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher STRA8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated STRA8 expression acts as an unfavorable survival marker, although some lineages such as OV and KIRP show a favorable association.

BLCA, DLBC, and OV are the cancer types where STRA8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.494	0.667	<.001	82	view →
DLBC	OS	Quartile	III,IV	0.120	0.797	<.001	81	view →
OV	DFS	Quartile	II,III,IV	0.447	0.312	.003	60	view →
KIRP	DFS	Median	II,III,IV	1.000	0.453	<.001	53	view →
COAD	DFS	Tertile	All	0.465	0.726	<.001	51	view →
BRCA	OS	Quartile	III,IV	0.722	0.869	.002	32	view →
HNSC	DFS	Tertile	All	0.460	0.246	<.001	32	view →
LIHC	OS	Median	III,IV	0.528	0.752	.002	31	view →
MESO	OS	Median	IV	0.787	0.371	.004	26	view →
THCA	OS	Tertile	III,IV	0.788	0.951	.008	24	view →
KIRC	DFS	Median	IV	0.708	0.523	.007	16	view →
CESC	DFS	Quartile	II,III,IV	0.529	0.823	.011	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

STRA8–BLCA (OS)

Open the BLCA breakdown →