STMN4

Across TCGA patient cohorts, STMN4 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STMN4-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and HER3_pY1289. Each is linked with STMN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STMN4-to-partner and partner-to-STMN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by STMN4-low versus STMN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STMN4→partner) and Y-score (partner→STMN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.879	+3.189	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.365	-2.584	.001	.011	3	1
UCEC	HER3_pY1289 →	-0.081	-2.980	.044	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.213	-2.999	.006	.035	3	1
UCEC	MYH11 →	+1.178	+2.584	.027	.011	3	1
UCEC	NF2 →	+0.260	+3.169	.010	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-7-cleavedD198 by STMN4 expression — UCEC

Explore this box plot interactively →