STK17B

Across TCGA patient cohorts, STK17B mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK17B-associated genes across cancer lineages are IRS1, Rab11, and CD49b. Each is linked with STK17B in more than 1 cancer types. Because this analysis shows association rather than direction, both STK17B-to-partner and partner-to-STK17B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by STK17B-low versus STK17B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK17B→partner) and Y-score (partner→STK17B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS1 →	+0.226	+2.321	.029	.035	3	1
UCEC	Rab11 →	-0.146	-3.150	.046	.019	3	1
UCEC	CD49b →	-0.302	-3.150	.034	.019	3	1
UCEC	C-Raf →	+0.171	+2.321	.017	.035	3	1
UCEC	Caspase-8 →	-0.299	-3.459	.017	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

IRS1 by STK17B expression — UCEC

Explore this box plot interactively →