STK17B

Across TCGA cell cohorts, STK17B mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible STK17B-associated genes across cancer lineages are CNTN6, IL2, and PRAMEF2. Each is linked with STK17B in more than 1 cancer types. Because this analysis shows association rather than direction, both STK17B-to-partner and partner-to-STK17B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNTN6 grouped by STK17B-low versus STK17B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK17B→partner) and Y-score (partner→STK17B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CNTN6 →	+0.221	+3.855	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	IL2 →	+0.036	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF2 →	+0.182	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	BPIFA3 →	+0.036	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	CYLC2 →	+0.016	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	KNCN →	+0.023	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

CNTN6 by STK17B expression — BLOOD_Leukemia

Explore this box plot interactively →