STK17B

Across TCGA cell cohorts, STK17B mutation is significantly associated with the mutation status of many other genes, with 1,274 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STK17B-associated genes across cancer lineages are SPATA7, REV3L, and SLC16A7. Each is linked with STK17B in more than 2 cancer types. Because this analysis shows association rather than direction, both STK17B-to-partner and partner-to-STK17B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA7 grouped by STK17B-low versus STK17B-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK17B→partner) and Y-score (partner→STK17B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SPATA7 →	+4.392	+4.954	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	REV3L →	+4.392	+4.954	.008	.008	1	3
LARGE_INTESTINE	SLC16A7 →	+2.407	+2.886	.008	.008	1	3
LARGE_INTESTINE	CORO6 →	+3.215	+3.415	.002	.002	1	3
BLOOD_Leukemia	KIAA0825 →	+4.145	+4.635	.001	.001	1	3
UPPER_AERODIGESTIVE_TRACT	ARNT →	+5.392	+5.392	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,274 associations by consensus.

SPATA7 by STK17B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →