STH

Across TCGA patient cohorts, STH mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STH-associated genes across cancer lineages are RNU6-463P, RNU7-82P, and OR5BM1P. Each is linked with STH in more than 1 cancer types. Because this analysis shows association rather than direction, both STH-to-partner and partner-to-STH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-463P grouped by STH-low versus STH-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STH→partner) and Y-score (partner→STH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-463P →	+0.363	+7.954	<.001	.008	3	1
HNSC	RNU7-82P →	+0.698	+7.954	<.001	.008	3	1
HNSC	OR5BM1P →	+0.174	+7.954	<.001	.008	3	1
BLCA	RPL31P9 →	+0.268	+7.640	<.001	.009	3	1
SKCM	OR4A45P →	+0.044	+7.816	<.001	.008	3	1
UCEC	MIR218-1 →	+0.826	+4.982	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

RNU6-463P by STH expression — HNSC

Explore this box plot interactively →