STH

Across TCGA pan-cancer cohorts, STH RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of STH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where STH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STH is over-expressed in tumor.

KIRC and BRCA are the cancer types where STH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.122	<.001	8	view →
BRCA	All	All	+0.220	.025	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

STH–KIRC

Open the KIRC breakdown →