STEAP3

Across TCGA cell cohorts, STEAP3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STEAP3-associated genes across cancer lineages are TMEM210, IL27, and BHLHA9. Each is linked with STEAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STEAP3-to-partner and partner-to-STEAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM210 grouped by STEAP3-low versus STEAP3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP3→partner) and Y-score (partner→STEAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TMEM210 →	+0.101	+4.472	<.001	.004	3	1
CNS	IL27 →	+0.042	+4.315	.003	.006	3	1
CNS	BHLHA9 →	+0.031	+5.044	<.001	.001	3	1
CNS	VN1R4 →	+0.073	+4.754	<.001	.005	3	1
SKIN	OR5T3 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	GALR3 →	+0.092	+3.602	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

TMEM210 by STEAP3 expression — CNS

Explore this box plot interactively →