STAT3

Across TCGA pan-cancer cohorts, STAT3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of STAT3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where STAT3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types STAT3 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

HNSC, PDAC, and LUAD are the cancer types where STAT3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STAT3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.374	<.001	11	view →
PDAC	Female	All	+0.493	<.001	7	view →
LUAD	Male	II,III,IV	+0.189	<.001	4	view →
COAD	Male	III,IV	−0.182	.007	2	view →
CCRCC	All	All	+0.060	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

STAT3–HNSC

Open the HNSC breakdown →