STARD8

Across TCGA patient cohorts, STARD8 mutation is significantly associated with the RNA expression of many other genes, with 6,081 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STARD8-associated genes across cancer lineages are NOL7, LDHAP7, and KRTAP5-9. Each is linked with STARD8 in more than 2 cancer types. Because this analysis shows association rather than direction, both STARD8-to-partner and partner-to-STARD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOL7 grouped by STARD8-low versus STARD8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STARD8→partner) and Y-score (partner→STARD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NOL7 →	+0.414	+2.353	.005	.003	3	3
UCEC	LDHAP7 →	+0.606	+2.113	<.001	<.001	3	3
UCEC	KRTAP5-9 →	-0.403	-1.754	<.001	<.001	3	3
UCEC	MMP12 →	+1.078	+2.091	<.001	<.001	3	3
UCEC	BAG1 →	+0.539	+2.169	<.001	<.001	3	3
UCEC	SLC25A11 →	+0.354	+2.002	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,081 associations by consensus.

NOL7 by STARD8 expression — SKCM

Explore this box plot interactively →