STARD8

Across TCGA pan-cancer cohorts, STARD8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of STARD8’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where STARD8 RNA is repressed in tumor relative to normal tissue. In most cancer types STARD8 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and LUAD are the cancer types where STARD8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STARD8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−1.422	<.001	11	view →
KICH	Female	All	−2.587	<.001	9	view →
LUAD	Female	III,IV	−2.214	<.001	9	view →
THCA	All	All	−0.428	.002	9	view →
LUSC	Female	II,III,IV	−2.758	<.001	8	view →
KIRP	Male	All	−2.062	<.001	8	view →
LIHC	Female	All	+0.840	<.001	7	view →
UCEC	All	All	−2.020	<.001	6	view →
BRCA	All	II,III,IV	−0.825	<.001	6	view →
COAD	All	All	−0.379	.002	6	view →
HNSC	Female	III,IV	+1.001	.001	4	view →
PRAD	All	All	−0.744	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

STARD8–BLCA

Open the BLCA breakdown →