STARD6

Across TCGA patient cohorts, STARD6 mutation is significantly associated with the RNA expression of many other genes, with 348 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STARD6-associated genes across cancer lineages are GHRLOS, RNA5SP412, and RN7SKP221. Each is linked with STARD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both STARD6-to-partner and partner-to-STARD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRLOS grouped by STARD6-low versus STARD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STARD6→partner) and Y-score (partner→STARD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GHRLOS →	+0.768	+3.225	<.001	.009	3	2
UCEC	RNA5SP412 →	+0.949	+2.967	<.001	.002	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
BLCA	RFC3P1 →	+0.049	+7.640	<.001	.009	3	2
UCEC	RNU4-58P →	+0.390	+3.548	<.001	.001	3	2
UCEC	RNU6-741P →	+0.463	+4.245	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 348 associations by consensus.

GHRLOS by STARD6 expression — UCEC

Explore this box plot interactively →