STAR

Across TCGA patient cohorts, STAR mutation is significantly associated with the RNA expression of many other genes, with 2,131 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAR-associated genes across cancer lineages are FAM74A7, RNU6-462P, and RFKP1. Each is linked with STAR in more than 1 cancer types. Because this analysis shows association rather than direction, both STAR-to-partner and partner-to-STAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM74A7 grouped by STAR-low versus STAR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAR→partner) and Y-score (partner→STAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FAM74A7 →	+0.065	+5.159	.005	.007	3	2
LGG	RNU6-462P →	+0.333	+7.977	<.001	.007	3	2
UCEC	RFKP1 →	+0.094	+2.564	<.001	.002	3	2
UCEC	BNIP3P41 →	+0.011	+4.230	<.001	.004	3	2
UCEC	ZFP64P1 →	+0.161	+1.786	.002	.006	3	2
OV	RNU6-581P →	+0.413	+5.137	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,131 associations by consensus.

FAM74A7 by STAR expression — SKCM

Explore this box plot interactively →