STAR

Across TCGA pan-cancer cohorts, STAR RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of STAR’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where STAR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STAR is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

LUSC, COAD, and BRCA are the cancer types where STAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+1.494	<.001	7	view →
COAD	Male	All	−0.148	<.001	7	view →
BRCA	Female	All	−0.182	<.001	6	view →
HNSC	All	All	+0.455	.005	4	view →
THCA	All	All	−0.161	<.001	4	view →
PRAD	All	All	−0.194	<.001	2	view →
KICH	All	All	−0.060	.009	2	view →
STAD	Male	III,IV	−0.266	.049	1	view →
BLCA	All	IV	−0.164	.027	1	view →
LUAD	All	All	+0.125	.038	1	view →
LIHC	All	All	+0.092	.028	1	view →
KIRP	Male	All	−0.047	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

STAR–LUSC

Open the LUSC breakdown →