STAR

Across TCGA cell cohorts, STAR mutation is significantly associated with the drug of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STAR-associated genes across cancer lineages are Temsirolimus, Lestaurtinib, and GSK2606414. Each is linked with STAR in more than 1 cancer types. Because this analysis shows association rather than direction, both STAR-to-partner and partner-to-STAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Temsirolimus grouped by STAR-low versus STAR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAR→partner) and Y-score (partner→STAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Temsirolimus →	+0.677	+2.678	.002	.037	3	1
LARGE_INTESTINE	Lestaurtinib →	+0.692	+2.710	.004	.043	3	1
LARGE_INTESTINE	GSK2606414 →	+0.458	+2.991	.012	.018	3	1
LARGE_INTESTINE	WYE-125132 →	+0.640	+2.874	.007	.021	3	1
LARGE_INTESTINE	CD532 →	+0.408	+2.874	.032	.021	3	1
LARGE_INTESTINE	GSK-LSD1 →	+0.274	+2.678	.047	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Temsirolimus by STAR expression — LARGE_INTESTINE

Explore this box plot interactively →