ST8SIA6

Across TCGA patient cohorts, ST8SIA6 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST8SIA6-associated genes across cancer lineages are p70-S6K_pT389, Notch1, and Shc_pY317. Each is linked with ST8SIA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ST8SIA6-to-partner and partner-to-ST8SIA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by ST8SIA6-low versus ST8SIA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA6→partner) and Y-score (partner→ST8SIA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.168	-2.321	.032	.033	3	3
UCEC	Notch1 →	+0.151	+2.321	.009	.006	3	2
UCEC	Shc_pY317 →	-0.153	-1.807	.014	.027	3	2
UCEC	14-3-3_beta →	-0.083	-3.143	.045	.018	3	1
UCEC	GATA6 →	-0.133	-1.693	.042	.044	3	1
UCEC	HSP70 →	-0.369	-2.312	.026	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

p70-S6K_pT389 by ST8SIA6 expression — UCEC

Explore this box plot interactively →