ST8SIA6

Across TCGA pan-cancer cohorts, ST8SIA6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ST8SIA6’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ST8SIA6 RNA is repressed in tumor relative to normal tissue. In most cancer types ST8SIA6 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

LUAD, KIRP, and LUSC are the cancer types where ST8SIA6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST8SIA6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−2.706	<.001	11	view →
KIRP	Female	All	−1.251	<.001	11	view →
LUSC	Female	II,III,IV	−2.969	<.001	9	view →
BLCA	Female	III,IV	−0.321	.005	8	view →
READ	All	All	−1.220	<.001	7	view →
COAD	Female	All	−1.184	<.001	7	view →
HNSC	Male	All	−0.567	<.001	7	view →
LIHC	Male	III,IV	−0.407	<.001	7	view →
STAD	All	II,III,IV	−0.473	.001	4	view →
THCA	Male	II,III,IV	−0.437	.022	3	view →
KICH	Male	IV	−2.076	.040	2	view →
CHOL	All	All	−0.226	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ST8SIA6–LUAD

Open the LUAD breakdown →