ST8SIA6

Across TCGA pan-cancer cohorts, ST8SIA6 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ST8SIA6 data layer compared with 5 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ST8SIA6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ST8SIA6 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LIHC show a favorable association.

BLCA, STAD, and BRCA are the cancer types where ST8SIA6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	II,III,IV	0.503	0.692	<.001	101	view →
STAD	OS	Median	All	0.350	0.496	.001	94	view →
BRCA	OS	Tertile	II,III,IV	0.971	0.927	.002	69	view →
MESO	OS	Quartile	II,III,IV	0.253	0.539	.002	62	view →
LIHC	OS	Median	II,III,IV	0.800	0.631	.001	36	view →
ESCA	DFS	Median	III,IV	0.555	0.312	.005	32	view →
ACC	DFS	Median	All	0.776	0.348	<.001	27	view →
READ	DFS	Quartile	III,IV	0.284	0.617	.011	16	view →
PRAD	DFS	Quartile	All	0.907	0.699	.006	14	view →
UVM	OS	Quartile	All	0.720	0.943	.015	13	view →
THCA	DFS	Median	IV	0.840	0.444	.004	10	view →
CESC	DFS	Quartile	All	0.422	0.664	.013	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ST8SIA6–BLCA (OS)

Open the BLCA breakdown →