ST8SIA5

Across TCGA cell cohorts, ST8SIA5 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ST8SIA5-associated genes across cancer lineages are ACTRT1, OR6C70, and MTRNR2L5. Each is linked with ST8SIA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST8SIA5-to-partner and partner-to-ST8SIA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTRT1 grouped by ST8SIA5-low versus ST8SIA5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA5→partner) and Y-score (partner→ST8SIA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACTRT1 →	+0.021	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR6C70 →	+0.025	+4.922	<.001	.009	3	1
BLOOD_Leukemia	MTRNR2L5 →	+0.033	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	OR1P1 →	+0.207	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ADAM7 →	+0.021	+4.922	.001	.009	3	1
LARGE_INTESTINE	GPR171 →	+0.016	+2.688	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ACTRT1 by ST8SIA5 expression — BLOOD_Leukemia

Explore this box plot interactively →