ST8SIA5

Across TCGA pan-cancer cohorts, ST8SIA5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ST8SIA5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ST8SIA5 RNA is repressed in tumor relative to normal tissue. In most cancer types ST8SIA5 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KICH, and KIRC are the cancer types where ST8SIA5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST8SIA5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−0.579	<.001	10	view →
KICH	Female	II,III,IV	+2.547	<.001	8	view →
KIRC	Male	III,IV	−0.700	<.001	8	view →
BRCA	All	All	+0.039	.009	6	view →
LIHC	All	All	+0.026	<.001	5	view →
COAD	All	II,III,IV	−0.017	.006	5	view →
THCA	Male	All	−0.064	<.001	4	view →
UCEC	All	All	+0.252	.036	2	view →
READ	All	All	−0.035	.018	2	view →
ESCA	All	All	−0.206	.029	1	view →
LUSC	All	All	+0.066	.039	1	view →
LUSC	Male	III,IV	−0.027	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

ST8SIA5–KIRP

Open the KIRP breakdown →