ST8SIA3

Across TCGA patient cohorts, ST8SIA3 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST8SIA3-associated genes across cancer lineages are S6_pS235_S236, S6_pS240_S244, and EGFR_pY1068. Each is linked with ST8SIA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST8SIA3-to-partner and partner-to-ST8SIA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS235_S236 grouped by ST8SIA3-low versus ST8SIA3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA3→partner) and Y-score (partner→ST8SIA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	S6_pS235_S236 →	-0.376	-1.807	.031	.026	3	2
SKCM	S6_pS240_S244 →	-0.372	-1.807	.029	.026	3	2
UCEC	EGFR_pY1068 →	-0.243	-2.999	.001	<.001	3	2
UCEC	eIF4E →	+0.151	+2.335	.019	.002	3	2
UCEC	FASN →	+0.237	+1.502	.049	.027	3	2
UCEC	GATA6 →	-0.104	-1.770	.035	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

S6_pS235_S236 by ST8SIA3 expression — SKCM

Explore this box plot interactively →