ST8SIA3

Across TCGA pan-cancer cohorts, ST8SIA3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ST8SIA3 data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ST8SIA3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ST8SIA3 expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

UCEC, LGG, and ACC are the cancer types where ST8SIA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	0.522	0.725	<.001	50	view →
LGG	DFS	Median	All	0.805	0.672	<.001	50	view →
ACC	DFS	Tertile	All	0.148	0.579	.007	32	view →
HNSC	OS	Tertile	All	0.470	0.636	.023	18	view →
COAD	DFS	Quartile	IV	0.202	0.546	<.001	18	view →
OV	OS	Median	II,III,IV	0.652	0.730	.024	16	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.017	16	view →
TGCT	DFS	Median	All	0.522	0.815	.001	16	view →
PAAD	DFS	Median	All	0.467	0.263	.009	15	view →
THCA	OS	Quartile	III,IV	0.699	0.949	.022	12	view →
KICH	OS	Tertile	II,III,IV	1.000	0.839	.031	12	view →
LIHC	OS	Quartile	II,III,IV	0.483	0.661	.030	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ST8SIA3–UCEC (OS)

Open the UCEC breakdown →