ST8SIA3

Across TCGA pan-cancer cohorts, ST8SIA3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ST8SIA3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ST8SIA3 RNA is repressed in tumor relative to normal tissue. In most cancer types ST8SIA3 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and STAD are the cancer types where ST8SIA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST8SIA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.209	<.001	8	view →
READ	All	All	−0.291	.003	4	view →
STAD	All	All	−0.153	.001	4	view →
THCA	All	All	−0.034	.002	2	view →
ESCA	All	All	−0.165	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ST8SIA3–COAD

Open the COAD breakdown →